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KMID : 1033620220490020101
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Clinical and Experimental Reproductive Medicine
2022 Volume.49 No. 2 p.101 ~ p.109
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Prevalence of Y chromosome microdeletions among infertile Mongolian men
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Damdinsuren Erdenesuvd
Naidansuren Purevjargal
Gochoo Mendsaikhan
Choi Bum-Chae
Choi Min-Youp
Baldandorj Bolorchimeg
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Abstract
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Objective: Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men.
Methods: A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined.
Results: Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%.
Conclusion: The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.
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KEYWORD
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Azoospermia, Infertility, Semen analysis, Y chromosome
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